Antidepressants associated with miscarriage

June 18, 2010

Use of antidepressants during pregnancy, particularly paroxetine, venlafaxine, or a combination of different antidepressant classes, may increase risk of miscarriage by 68 percent, according to researchers.

CMAJ.[online] May 31, 2010. http://www.cmaj.ca/cgi/content/abstract/cmaj.091208v1. Accessed June 2, 2010.

Use of antidepressants during pregnancy, particularly paroxetine, venlafaxine, or a combination of different antidepressant classes, may increase the risk of miscarriage by 68 percent, according to researchers from the University of Montreal. They conducted a nested case-control study of 5,124 women who had a spontaneous abortion, each of whom were matched to 10 randomly selected controls, and assessed the presence or absence of antidepressant exposure to determine whether the use of antidepressants increases the risk of miscarriage. The researchers found that 5.5 percent of the women who miscarried had at least one prescription for an antidepressant filled during the pregnancy, compared with 2.7 percent of the matched controls.